Question

1 What does TX do to voltage-gated Nat channels?

Answer 1

TX, also known as tetrodotoxin, is a potent neurotoxin that primarily affects voltage-gated sodium (Na⁺) channels. It binds to the extracellular portion of these channels, specifically to a site on the channel protein, which prevents the flow of sodium ions through the channel. This action blocks the depolarization of the neuronal membrane, effectively inhibiting action potentials and the transmission of nerve impulses. As a result, tetrodotoxin can lead to paralysis and can be lethal at high doses due to its effects on nerve signal conduction.