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This is the original strand of DNA: ATG AAG TTT GGC TAA

Which option would represent a frameshift mutation due to deletion during replication?



(1 point)
Responses

ATG UAA GTT TGG CTA A
ATG UAA GTT TGG CTA A

ATG AAG TTT GGC GCA TAA
ATG AAG TTT GGC GCA TAA

ATG AAG TTG GCT AA
ATG AAG TTG GCT AA

ATG TTT GGC TAA

1 answer

A frameshift mutation occurs when nucleotides are added or deleted from the DNA sequence, shifting the reading frame of the codons. In this case, we're looking for an option that deletes one or more nucleotides from the original sequence "ATG AAG TTT GGC TAA."

Let's analyze the provided options:

  1. ATG UAA GTT TGG CTA A - This option isn't a deletion; it is a change of bases and doesn't preserve the original sequence.

  2. ATG AAG TTT GGC GCA TAA - This option includes an additional nucleotide (G) and is therefore not a deletion.

  3. ATG AAG TTG GCT AA - This option is missing the nucleotide "T" from the original sequence, resulting in a deletion that changes the reading frame for the subsequent codons.

  4. ATG TTT GGC TAA - This option is missing "AAG" from the original sequence, resulting in a deletion that also changes the reading frame.

Both options 3 and 4 represent frameshift mutations due to deletion. However, since the question specifically asks for an example of a frameshift mutation due to a deletion, the best choice would be:

ATG AAG TTG GCT AA (Option 3)

This maintains the first part of the original sequence while deleting one nucleotide.