Question

Which of the following can be used to predict the 3-D structure of the protein?

side chains of various amino acids
peptide bonds between different amino acids
number of water molecules in the vicinity
sequence of amino acids in the polypeptide chain
GPT-4o mini
The most direct factor that can be used to predict the 3-D structure of a protein is the **sequence of amino acids in the polypeptide chain**. The specific order of the amino acids determines how the protein will fold and its resulting 3-D conformation. Other factors like side chains, peptide bonds, and the environment (such as the number of water molecules) can influence folding or stability but the primary determinant is the amino acid sequence.

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