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The differences in the economic development of the mid-Atlantic (Middle Colonies), New England, and Southern colonies can BEST be attributed to the **geographic conditions there**.
Geographic factors such as climate, soil quality, and access to waterways greatly influenced the types of agriculture and industry that developed in each region. The Mid-Atlantic colonies had fertile land suitable for diverse crops, New England’s rocky soil and colder climate led to a focus on trade, fishing, and small-scale farming, while the Southern colonies had a warm climate and fertile soil suitable for cash crops like tobacco and rice.