The statement that accurately compares and contrasts eukaryotes and prokaryotes is:
Eukaryotes have a true nucleus and membrane-bound organelles, while prokaryotes lack a true nucleus and organelles.
This statement correctly reflects the fundamental differences between these two types of cells. Eukaryotic cells have a defined nucleus and organelles enclosed by membranes, whereas prokaryotic cells do not have a nucleus and typically lack membrane-bound organelles.