2 | VARIATIONS OF PRECAUTIONARY PRINCIPLES
Defining the precautionary principle precisely is challenging due to its various interpretations, which can differ significantly. It can be seen as a guideline for choosing the optimal course of action, a rule influencing our beliefs, or a procedural standard that policymakers should adhere to when making decisions involving risks. In this article, we focus on the precautionary principle as a rule of choice, aligning with its typical application in bioethics. This perspective is particularly relevant to our key inquiry: how should we assess the risks and benefits of interventions in the human germline?
Even when limiting our focus to the precautionary principle as a rule of choice, it remains multifaceted. A common differentiation exists between weak and strong forms of the precautionary principle. We parallel this with negative and positive precautionary principles. This distinction is outlined as follows:
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Negative precautionary principle: We should not refrain from taking precautionary measures because we lack certainty that an activity will cause harm.
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Positive precautionary principle: We should implement some form of precautionary action against activities that could potentially cause harm.
Negative versions do not explicitly indicate when precautionary actions should be taken; they simply reject one rationale against such actions. In contrast, positive precautionary principles mandate decision-makers to adopt precautionary steps against specific threats. These positive principles can vary widely in their demands, based on the perceived threats, the recommended remedies, and the strength of these recommendations.
For instance, consider these two hypothetical positive precautionary principles:
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Strong positive precautionary principle: Extensive precautionary actions must be taken to completely eliminate any possible threats to human well-being, regardless of associated costs, the likelihood of the threat occurring, or the potential harm it may cause.
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Weak positive precautionary principle: Minimal precautionary measures should be considered against catastrophic threats to human well-being that are highly likely to happen.
Both principles are positive; however, the first advocates for extensive measures across broad conditions, while the second suggests only basic precautions against the most severe risks. The first principle is overly stringent, while the second is insufficiently demanding. Yet, it's possible that a moderate positive precautionary principle could offer a practical framework for decision-making.
Certain interpretations of the precautionary principle explicitly address the burden of proof, requiring those proposing potentially risky activities to demonstrate their safety. In such cases, proponents of precautionary measures are not obligated to show that the activity is harmful before implementing precautions. While this article does not delve into burden of proof considerations, we maintain that such requirements are tools to further the goal of the precautionary principle—namely, to prioritize the avoidance of certain negative outcomes.
Next, we analyze whether negative and positive versions of the precautionary principle should influence our evaluation of the risks and benefits of germline gene editing (GGE). We conclude that while the precautionary principle plays a valid role in the ethical considerations of GGE, its application is not as clear-cut as some might believe. Our conclusions are twofold: no reasonable version of the precautionary principle suggests that we should completely reject GGE in human reproduction, and it can still guide the development of GGE by prioritizing certain applications over others.