To find the change in the amount of water removed per minute, we start by calculating the rate at which the pump removes water.
The pump removes 250 gallons of water in 5 minutes. To find the amount removed in 1 minute, we divide the total amount by the number of minutes:
\[ \text{Gallons per minute} = \frac{250 \text{ gallons}}{5 \text{ minutes}} = 50 \text{ gallons per minute} \]
Since this amount is being removed from the tank, the change in the amount of water is negative. Therefore, the change in the amount of water in 1 minute is:
\[ \text{Change} = -50 \text{ gallons} \]
Thus, the correct response is:
−50 (negative 50)