To simplify the expression \( \frac{2^2}{2^{-4}} \) using the properties of integer exponents, we can use the quotient of powers property, which states that:
\[ \frac{a^m}{a^n} = a^{m-n} \]
In this case, we can apply this property:
\[ \frac{2^2}{2^{-4}} = 2^{2 - (-4)} = 2^{2 + 4} = 2^6 \]
Now, we can calculate \( 2^6 \):
\[ 2^6 = 64 \]
Thus, the equivalent expression simplifies to a whole number, which is
\[ \boxed{64} \]