Question

sickle cell anemia What type of mutation error has occurred to cause the disorder shown?(1 point)
Responses

frameshift
frameshift

insertion
insertion

deletion
deletion

substitution

Answer 1

Sickle cell anemia is caused by a **substitution** mutation. Specifically, it is a point mutation where adenine (A) is replaced by thymine (T) in the HBB gene, leading to the substitution of glutamic acid with valine in the hemoglobin protein. This change in the amino acid sequence is what causes red blood cells to become rigid and sickle-shaped.