To simplify the expression
\[ \frac{2^4}{(2^{-6})^{-1}}, \]
we start with the denominator \((2^{-6})^{-1}\). We can use the property of exponents that states \((a^m)^n = a^{m \cdot n}\). Thus,
\[ (2^{-6})^{-1} = 2^{-6 \cdot (-1)} = 2^6. \]
Now, substitute \(2^6\) back into the expression:
\[ \frac{2^4}{2^6}. \]
Next, we can use the property of exponents that states \(\frac{a^m}{a^n} = a^{m-n}\):
\[ \frac{2^4}{2^6} = 2^{4-6} = 2^{-2}. \]
Now we have simplified the original expression to \(2^{-2}\).
Looking at the multiple-choice answers, the equivalent expression is:
\[ 2^{-2}. \]
So, the answer is:
2, to the power minus 2 (-2).