The statement that BEST explains why the decision made in the "Dred Scott" case nullified the Compromise of 1850 and "popular sovereignty" is:
Slaves were considered property and the federal government could not disallow slavery in any state.
This reflects the ruling in the Dred Scott case, which stated that because slaves were considered property, the federal government had no authority to prohibit slavery in the territories, thereby undermining the principles of popular sovereignty and nullifying the compromises related to slavery made in the 1850s.