Let's denote the number of boxes Mrs. Nelson needs to buy as \( x \).
- Mrs. Nelson currently has 25 bottles.
- She needs a total of 200 bottles.
- Each box contains 20 bottles.
The total number of bottles she will have after buying \( x \) boxes is the sum of the bottles she already has and the bottles from the boxes she buys. This can be expressed as:
\[ 25 + 20x \]
We want this total to equal 200 bottles, so we can set up the equation:
\[ 25 + 20x = 200 \]
This equation shows how many more boxes of hand sanitizer Mrs. Nelson needs to purchase.