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To simplify the expression \( \frac{2^2}{2^{-4}} \) using the properties of integer exponents:
1. Recall the property of exponents that states \( \frac{a^m}{a^n} = a^{m-n} \).
2. Apply this property here by rewriting \( \frac{2^2}{2^{-4}} \) as:
\[
2^{2 - (-4)} = 2^{2 + 4} = 2^6
\]
Now, calculate \( 2^6 \):
\[
2^6 = 64
\]
Therefore, the expression \( \frac{2^2}{2^{-4}} \) simplifies to \( 64 \) as a whole number.
So, the final answer is:
\[
\boxed{64}
\]