The correct response that highlights a difference between gene regulation in prokaryotes and eukaryotes is:
Prokaryotes do not store their genes in a nucleus like eukaryotes do.
This statement accurately reflects a fundamental structural difference between prokaryotic and eukaryotic cells, affecting how gene regulation occurs. Prokaryotes have their genetic material in a nucleoid region without a membrane, while eukaryotes have their DNA enclosed within a nuclear membrane, leading to distinct regulatory mechanisms.
The other options provided contain inaccuracies or misrepresentations of gene regulation processes between the two groups.