To divide the fractions \(-\frac{3}{4}\) by \(\frac{3}{8}\), you can multiply by the reciprocal of the second fraction.
Thus, the calculation is:
\[ -\frac{3}{4} \div \frac{3}{8} = -\frac{3}{4} \times \frac{8}{3} \]
Now, multiply the fractions:
\[ -\frac{3 \times 8}{4 \times 3} \]
The \(3\) in the numerator and denominator cancels out:
\[ -\frac{8}{4} = -2 \]
Thus, the quotient when you divide \(-\frac{3}{4}\) by \(\frac{3}{8}\) is \(-2\).
So the correct response is:
\(-2\)