To simplify the expression \((2xy^3)^4 \cdot (x^2y)^3\), we will apply the properties of integer exponents.
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Start with the first term \((2xy^3)^4\):
- \( (2^4)(x^4)(y^{3 \cdot 4}) = 16x^4y^{12} \)
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Now simplify the second term \((x^2y)^3\):
- \( (x^{2 \cdot 3})(y^3) = x^6y^3 \)
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Now we can multiply the two results together: \[ (16x^4y^{12}) \cdot (x^6y^3) \]
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Combine the coefficients and terms:
- Coefficient: \( 16 \cdot 1 = 16 \)
- For \(x\): \( x^4 \cdot x^6 = x^{4+6} = x^{10} \)
- For \(y\): \( y^{12} \cdot y^3 = y^{12+3} = y^{15} \)
So, the simplified expression is: \[ 16x^{10}y^{15} \]
Therefore, the correct option is: 16x^{10}y^{15}.