To simplify the expression \( 2^4 \cdot 2^2 \) using the Product Rule of Exponents, we add the exponents together since the bases are the same. The Product Rule states that:
\[ a^m \cdot a^n = a^{m+n} \]
Applying this rule:
\[ 2^4 \cdot 2^2 = 2^{4+2} = 2^6 \]
So, the simplified expression is:
\[ 2^6 \]