The correct choice that compares prokaryotic and eukaryotic chromosomes is:
Prokaryotes tend to only have one chromosome while eukaryotes have many.
Prokaryotic chromosomes are generally circular and not linear, and they do not have nucleosomes in the same manner as eukaryotic chromosomes, which are linear and organized around histone proteins to form structures called nucleosomes. Additionally, prokaryotic chromosomes are typically smaller than eukaryotic ones.