The correct choice for comparing prokaryotic and eukaryotic chromosomes is:
Prokaryotes tend to only have one chromosome while eukaryotes have many.
To briefly explain the other options:
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Prokaryotic chromosomes are typically much larger than eukaryotic ones. - This is incorrect; eukaryotic chromosomes are generally larger and more complex than prokaryotic ones.
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Prokaryotic chromosomes are wrapped into structures called nucleosomes. - This is incorrect; nucleosomes are structures found in eukaryotic cells, where DNA is wrapped around histone proteins. Prokaryotes do not have nucleosomes.
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Prokaryotic chromosomes are linear while eukaryotic chromosomes are circular. - This is incorrect; prokaryotic chromosomes are typically circular while eukaryotic chromosomes are linear.
Therefore, the second option is the only correct comparison.