To simplify the expression \( 2^4 \times 2^2 \) using the Product Rule of Exponents, you add the exponents when multiplying like bases. The rule states:
\[ a^m \times a^n = a^{m+n} \]
Applying this to the given expression:
\[ 2^4 \times 2^2 = 2^{4+2} \]
Now, calculate the sum of the exponents:
\[ 4 + 2 = 6 \]
Thus, the expression simplifies to:
\[ 2^6 \]
So, \( 2^4 \times 2^2 = 2^6 \).