To simplify \( -3i(4i + 5i) \), we start by combining the terms inside the parentheses:
\[ 4i + 5i = 9i \]
Now, substituting this back into the expression, we have:
\[ -3i(9i) \]
Next, we can multiply these two terms:
\[ -3i \cdot 9i = -27i^2 \]
Recall that \( i^2 = -1 \). Thus:
\[ -27i^2 = -27(-1) = 27 \]
So the expression simplifies to:
\[ 27 \]
Therefore, the answer is \( \boxed{27} \).