The most accurate response regarding the impact of colonial leadership on Spanish settlement in South Carolina is:
Efforts to exploit local Indigenous peoples created long-term problems between Spanish settlers and Indigenous Americans.
This statement highlights the negative consequences of the tribute system implemented by colonial leaders, which aimed at exploiting Indigenous peoples for economic gain. Such practices often led to resistance, conflict, and deteriorating relationships between Spanish settlers and Indigenous communities, ultimately influencing the sustainability and success of Spanish settlements in the region.