To divide \(-\frac{3}{4}\) by \(\frac{3}{8}\), you can multiply by the reciprocal of \(\frac{3}{8}\).
\[ -\frac{3}{4} \div \frac{3}{8} = -\frac{3}{4} \times \frac{8}{3} \]
Now, multiply the numerators and the denominators:
\[ -\frac{3 \times 8}{4 \times 3} = -\frac{24}{12} \]
Now simplify:
\[ -\frac{24}{12} = -2 \]
So, the quotient when you divide \(-\frac{3}{4}\) by \(\frac{3}{8}\) is \(-2\).
The correct response is \(\text{negative } 2\).