To simplify \(\frac{x^{10}}{x^{-6}}\), you can use the properties of exponents, specifically the rule that states:
\[ \frac{a^m}{a^n} = a^{m-n} \]
Applying this rule, we have:
\[ \frac{x^{10}}{x^{-6}} = x^{10 - (-6)} = x^{10 + 6} = x^{16} \]
Thus, the simplified form is:
\[ \boxed{x^{16}} \]