To simplify the expression \( \sqrt{25} \cdot \sqrt{49} \), we can first calculate each square root separately.
\[ \sqrt{25} = 5 \] \[ \sqrt{49} = 7 \]
Now, we multiply these results together:
\[ \sqrt{25} \cdot \sqrt{49} = 5 \cdot 7 = 35 \]
Thus, the product of the expression in simplest radical form is
\[ \boxed{35} \]