Question

Anilide may replace by H or akyl in sulfonamides?

Answer 1

In sulfonamides, an anilide (the phenyl amine derivative of sulfonamide) can potentially be modified by replacing the anilide nitrogen's hydrogen (H) with another alkyl group. This modification can result in an N-alkyl sulfonamide.

However, the specific reactivity and potential for substitution depend on the structure of the sulfonamide and the conditions of the reaction. In general, sulfonamides can be synthesized or modified to incorporate various substituents, including alkyl groups, on the nitrogen atom.

It's important to ensure that the resultant compound maintains its desired properties for the intended application, particularly if the goal is to retain antibacterial activity, as variations in the alkyl chain can affect efficacy. So, yes, anilide in sulfonamides can be replaced by hydrogen or an alkyl group under appropriate chemical conditions.