Question
explain on a molecular level on how MCMV works
Answers
GPT 3.5
Mouse cytomegalovirus (MCMV) infects host cells by using a variety of molecular mechanisms. First, MCMV attaches to host cell receptors, such as integrins or heparan sulfate proteoglycans, on the cell surface. This attachment is mediated by viral glycoproteins on the surface of the virus.
Once attached, MCMV enters the host cell through endocytosis, where the virus is engulfed by a vesicle and brought into the host cell. The virus then escapes from the endosome into the cytoplasm, where it releases its genetic material – double-stranded DNA – into the host cell.
The viral DNA is then transported to the nucleus, where it is replicated using host cell machinery. This leads to the production of viral proteins and new viral genomes, which are then assembled into new virus particles.
MCMV also has mechanisms to evade the host immune response. For example, the virus can inhibit the cell's antiviral response by blocking the production of interferons, which are signaling molecules that coordinate the immune response to viral infection.
Overall, MCMV infects host cells by attaching to cell surface receptors, entering the cell through endocytosis, replicating its DNA in the host cell nucleus, and evading the host immune response. This allows the virus to establish a successful infection and persist in the host organism.
Once attached, MCMV enters the host cell through endocytosis, where the virus is engulfed by a vesicle and brought into the host cell. The virus then escapes from the endosome into the cytoplasm, where it releases its genetic material – double-stranded DNA – into the host cell.
The viral DNA is then transported to the nucleus, where it is replicated using host cell machinery. This leads to the production of viral proteins and new viral genomes, which are then assembled into new virus particles.
MCMV also has mechanisms to evade the host immune response. For example, the virus can inhibit the cell's antiviral response by blocking the production of interferons, which are signaling molecules that coordinate the immune response to viral infection.
Overall, MCMV infects host cells by attaching to cell surface receptors, entering the cell through endocytosis, replicating its DNA in the host cell nucleus, and evading the host immune response. This allows the virus to establish a successful infection and persist in the host organism.