Question

Which mutation caused the biggest change in the amino acids/proteins produced by the DNA sequence?

Answer 1

The mutation that causes a frame-shift in the DNA sequence typically results in the biggest change in the amino acids/proteins produced. This is because a frame-shift mutation adds or deletes nucleotides in a way that shifts the reading frame of the genetic code, leading to a completely different amino acid sequence downstream of the mutation site. This results in a non-functional or drastically altered protein product.