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To simplify the expression 15x - 5y^6z - 325x - 3y^-2, we combine like terms by adding or subtracting coefficients.
15x - 325x simplifies to -310x.
-5y^6z - 3y^-2 simplifies to -5y^6z - 3/y^2.
Therefore, the expression simplifies to:
-310x - 5y^6z - 3/y^2