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To simplify the expression 2^2 / 2^-4, we can use the rule of division of exponents where we subtract the exponents.
2^2 = 2 * 2 = 4
2^-4 = 1/2^4 = 1/16
Therefore, the expression simplifies to 4 / (1/16). To divide by a fraction, we multiply by its reciprocal, so we have:
4 * (16/1) = 4 * 16 = 64
Therefore, the solution as a whole number is 64.