Rate-limiting step in renin-angiotensin II- aldosterone axis.
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The rate-limiting step in the renin-angiotensin II-aldosterone axis is the conversion of angiotensinogen to angiotensin I by the enzyme renin. This step determines the overall rate of angiotensin II production, as it is the precursor for angiotensin II synthesis. Once angiotensin I is formed, it can be further converted to angiotensin II by the action of angiotensin-converting enzyme (ACE). However, the rate of conversion by ACE is typically much faster than the rate of renin release, making the renin release step the rate-limiting one.