Question

cortisol exist in free or bind form

Answer 1

Cortisol exists in both free and bound forms in the body. The majority of cortisol in the bloodstream is bound to corticosteroid-binding globulin (CBG) or albumin, resulting in the bound form. However, a small portion of cortisol remains unbound, which is the free form and is biologically active. It is the free form of cortisol that is able to bind to glucocorticoid receptors in target tissues and exert its effects.