In individuals with Congenital Insensitivity to Pain with Anhidrosis (CIPA), also known as Hereditary Sensory and Autonomic Neuropathy type IV (HSAN IV), several types of sensory receptors are affected by this condition. Specifically, CIPA affects the nociceptors and thermoreceptors in the body.
1. Nociceptors: Nociceptors are sensory receptors responsible for detecting pain stimuli, such as extreme heat, cold, pressure, or tissue damage. In people with CIPA, nociceptors are affected, leading to an inability to perceive pain.
2. Thermoreceptors: Thermoreceptors are sensory receptors that detect changes in temperature. There are two types of thermoreceptors: cold receptors and warm receptors. Cold receptors respond to cooling stimuli, while warm receptors respond to warming stimuli. In CIPA, the thermoreceptors are also affected, resulting in the inability to perceive temperature changes.
Due to the impairment of these sensory receptors, individuals with CIPA have an inability to feel pain or temperature, leading to an increased risk of sustaining injuries or experiencing burns without realizing it.
a person who has the conditions c i p a is unable to feel pain or temperature which sensory receptors are affected by this condition
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