Which of the following would be an appropriate scale of measurement for a scaled map of a large region?

D 1 inch = 10 miles

The appropriate scale of measurement for a scaled map of a large region would depend on the size of the region and the level of detail required.

If the region is relatively small and detailed, option D (1 inch = 10 miles) would be more appropriate for capturing finer details.

However, if the region is larger and less detailed information is needed, option B (1 inch = 100 miles) or even option C (1 inch = 1,000 miles) might be more suitable.

Ultimately, the choice of scale will depend on the specific needs and requirements of the map.