1.)The silica that makes up the stationary phase in TLC chromatophraphy is more polar than the mobile phase. What then might the relative positions of the analgesics on the developed TLC plate tell you about the polarity of these molecules? Does this match the expectations based on their structures?

Question

1.)The silica that makes up the stationary phase in TLC chromatophraphy is more polar than the mobile phase. What then might the relative positions of the analgesics on the developed TLC plate tell you about the polarity of these molecules? Does this match the expectations based on their structures?
 
2.) How can TLC be used to test the purity of a substance?

DrBob222 · Answer

The more polar compounds will "stick" to the polar TLC surface longer; therefore, the non-polar compounds will move up the TLC plate faster than the polar substituents will.

2. A PURE compound will move as one "spot" up the plate. Impurities will give a second and/or third spot (or more).