Voices that are high and low have more to do with where those voices are on the musical scale, not in loudness.
1 and 4 are opposites.
2 and 3 are opposites.
5 is odd, but not necessarily incorrect.
1. She spoke in a very loud voice.
2. She spoke in a very high voice.
3. She spoke in a very low voice.
4. She spoke in a very soft voice.
5. She spoke with a very loud voice.
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Does #1 mean #2? Can we use both #3 and #4? What about #5? Can we use 'with' in place of 'in'?
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