1. He is working in the building.

2. He is working at the building.
[Is #2 wrong? Can we use 'at' in the sentence?]

3. The boy is waiting for me in the bathroom.
4. The boy is waiting for me at the bathroom.
5. The boy is waiting for me by the bathroom.
[Is #4 wrong? Or does #4 mean #5?]

6. He is watching TV in the living room.
7. He is watching TV at the living room.
[Can't we use 'at' here?]

8. She is cooking in the kitchen.
9. She is cooking at the kitchen.
[Can't we use 'at' here?]

2 answers

1. He is working in the building.
2. He is working at the building.
[Is #2 wrong? Can we use 'at' in the sentence?] Both can be used, but they may or may not mean the same thing. 1 means he works INSIDE the building. 2 can mean he works inside or outside the building.

3. The boy is waiting for me in the bathroom.
4. The boy is waiting for me at the bathroom.
5. The boy is waiting for me by the bathroom.
[Is #4 wrong? Or does #4 mean #5?] Again, "in" in 3 means inside. 4 and 5 mean he's waiting just outside or near the bathroom door.

6. He is watching TV in the living room.
7. He is watching TV at the living room.
[Can't we use 'at' here?] No, 7 is incorrect.

8. She is cooking in the kitchen.
9. She is cooking at the kitchen.
[Can't we use 'at' here?] No, 9 is incorrect unless you mean an outdoor kitchen. If it's an outdoor kitchen, "at" might work, but not for a kitchen inside the house.
Thank you so much.