Insulin inhibits lipolysis by activating

Answer 1

Insulin inhibits lipolysis primarily by activating the enzyme lipoprotein lipase (LPL) and inhibiting hormone-sensitive lipase (HSL) in adipose tissue. When insulin binds to its receptors on adipocytes (fat cells), it triggers a signaling cascade that leads to the activation of phosphodiesterase, which decreases cyclic AMP (cAMP) levels. Lower levels of cAMP result in reduced activation of protein kinase A (PKA), which in turn inhibits the activity of hormone-sensitive lipase, a key enzyme responsible for breaking down stored triglycerides into free fatty acids and glycerol. Therefore, insulin effectively suppresses lipolysis and promotes fat storage.